学术带头人
[ 作者:科研管理     来源:哈尔滨医科大学(大庆)     点击数:4575     更新时间:2014/6/6     文章录入:科研管理
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 朱大岭,博士,博士研究生导师,哈尔滨医科大学大庆校区校长。首批“龙江学者”特聘教授,黑龙江省生物医药工程重点实验室——省部共建国家重点实验室培育基地副主任;美国Wisconsin医学院客座教授;国家和黑龙江省政府特殊津贴专家;黑龙江省领导直接联系专家;“863”课题评审专家;国家自然科学基金委员会第十三、第十四届生命科学部生理学与整合生物学专家评审组成员;Cancer Investigation,Apoptosis等著名国际学术期刊审稿人。
  承担和完成科研项目31项。获批项目资助经费1000余万元。其中包括: 国家自然科学国家自然科学基金重大研究计划1项,国家自然科学基金面上项目5项;国家自然科学基金对外交流与合作项目3项;“863”项目子课题3项;国家科技攻关计划-中国人类肝脏蛋白质组计划子课题1项,美国心脏病学会课题一项及省市重大项目多项;作为主要参加者完成美国NIH课题2项;作为第一完成人获教育部高等学校科学研究优秀成果二等奖(自然类),黑龙江省政府自然科学一等奖1项,二等奖2项,三等奖3项;获国家发明专利3项。
  主要论著
  2008至今,作为责任作者发表有关SCI收录文章48篇,影响因子大于4的14篇,大于5的5篇:
  1、Lei Guo, Xiaobo Tian , Hua Tian,Ye Liu, Zhigang Wang , Hong Wu, Jing Wang, Sholi Guo, Daling Zhu *.Subacute hypoxia suppresses Kv 3.4 channel expression and whole-cell K+ currents through endogenous15-hydroxyeicosatetraenoic acid in pulmonary arterial smooth muscle cells. European Journal of Pharmacology. 2008; 587(10) :187-195. (IF. 2.585)
  2、Xiaodong Zheng,QianLi, XiaoboTang, Shujun Liang, Lipeng Che, Shuang Zhang, Zhigang Wang, Lei Guo,Rong Zhang, Daling Zhu *.Source of the elevation Ca2+ evoked by 15-HETE in pulmonary arterial myocytes. European Journal of Pharmacology. 2008 ;601:16-22. (IF. 2.585)
  3、Xiaobo Tang, Rong Zhang, Zhigang Wang, Lei Yu, Shanshan Li ,Daling Zhu *. Influence of the 15-HETE on Cytosolic [Ca2+]i of the Rabbit Pulmonary Artery Smooth Muscle Cells. Brazilian archibes of biology and technology. 2008 ;51(2) : 281-286. (IF. 0.447)
  4、Zhigang Wang, Xiaobo Tang, Yumei Li, Changlian Lu, Lei Guo, Xiaodong Zheng, Daling Zhu *.20-Hydroxyeicosatetraenoic acid inhibits the apoptotic responses in pulmonary artery smooth muscle cells. European Journal of Pharmacology. 2008 ;588(1):9-17. (IF. 2.585)
  5、Xiaobo Tang, Hong Wu, Zhenghua Wu, Guiyu Wang, Daling Zhu *.Carboxylesterase 2 is Downregulated in Colorectal Cancer Following Progression of the Disease. Cancer Investigation. 2008 ;26(2):178-181 .(IF. 2.65)
  6、Jianing Zhang, Xiaobo Tang, Changlian Lu, Daling Zhu *.Staurosprine aglycone bilaterally regulates ERK1/2 phosphorylation in rat pulmonary artery smooth muscle cells.  Canadian Journal of  Physiology and Pharmacology.  2008; 86 (7):424-430. (IF. 1.341)
  7、FJ Qu, Y Liu, Daling Zhu *.Construction of tissue-engineered cartilage with BMP7 gene-transfected chondrocytes. The journal of international medical research. 2008; 36(4):837-847 (IF. 0.938)
  8、Ye Liu, Xiaobo Tang, Changlian Lu, WeinaHan, Shouli Guo, Daling Zhu *. Expression of 15-lipoxygenases in pulmonary arteries after hypoxia. Pathology .2009; 41(5):476-483. (IF. 2.673)
  9、Xiaojie Chu, XiaoboTang , Lei Guo, Hongxia Bao, Daling Zhu*. Hypoxia suppresses KV1.5 channel expression through endogenous 15-HETE in rat pulmonary artery. Prostaglandins & Other Lipid Mediators .2009 ;88(1-2):42-50. (IF. 2.557)
  10、Yumei Li, QianLi, Zhigang Wang, Di Liang , Daling Zhu *.15-HETE suppresses K+ channel activity and inhibits apoptosis in pulmonary artery smooth muscle cells. Apoptosis. 2009 ;14(1):42-51. (IF. 4.066)
  11、Lei Guo,Xiaobo Tang , Xiaojie Chu, Daling Zhu *.Roles of protein kinase C in 15-HETE induced pulmonary artery vasoconstriction. Prostaglandins Leukotrienes and Essential Fatty Acids.2009;80(2-3):115-123. (IF. 3.24)
  12、Wei Wang, Adachi, Masaaki, Rong Zhang,, Jin Zhou, Daling Zhu *. A Novel Combination Therapy With Arsenic Trioxide and Parthenolide Against Pancreatic Cancer. Pancreas. 2009;38(4):e114-e123. (IF. 2.733)
  13、Jun Ma, Shujun Liang, Zhigang Wang, Lei Zhang, Jing Jiang, Daling Zhu *.ROCK Pathway Participates in the Processes that 15-Hydroxyeicosatetraenoic Acid       
(15-HETE) Mediated the Pulmonary Vascular Remodeling Induced by Hypoxia in Rat.  Journal of Cellular Physiology. 2010; 222(1):82-94 (IF. 4.218)
  14、Shuang Wang, Yali Wang, Jing,Jiang ,Ruifang Wang, Lisa Li, Zhaoping Qiu, Hong Wu, Daling Zhu *.15-HETE protects rat pulmonary arterial smooth muscle cells from apoptosis via the PI3K/Akt pathway. Prostaglandins and Other Lipid Mediators. 2010; 91(1-2):51-60 (IF. 2.705)
  15、Yali Wang, Di Liang, Shuang Wang, Zhaoping Qiu, Xiaojie Chu, Shuo Chen, Lisa Li, Xiaiwei Nie, Rong Zhang, Zhigang Wang, Daling Zhu *.Role of the G-protein and tyrosine kinase-Rho/ROK pathways in 15-hydroxy- eicosatetraenoic acid induced pulmonary vasoconstriction in hypoxic rats. The Journal of Biochemistry. 2010;147(5):751-764 (IF. 2.371)
  16、Weiwei Shi, Ningren Cui, Zhongying Wu, Yang Yang, Shuang Zhang, Hongyu Gai, Daling Zhu*, Chun Jiang*. Lipopolysaccharides up-regulate Kir6.1/SUR2B channel expression and enhance vascular KATP channel activity via NF-kappaB-dependent signaling. The Journal of Biological Chemistry. 2010;    285(5):3021-3029 (IF. 5. 32)
  17、Jun Ma, Lei Zhang, Shanshan Li, Shulin Liu, Cui Ma, Weiyuan Li, J.R .Falck, V.L ,Sudarshan Reddyd, Meetha Medhorae, Elizabeth R. Jacobse, Daling Zhu *.8,9-EET analog protects pulmonary artery smooth muscle cells from apoptosis via ROCK pathway. Experimental Cell Research. 2010;316(14):2340-2453 . (IF. 3.589)
  18、Lei Guo, Zhaoping Qiu, Lei Zhang, Shuo Chen, Daling Zhu*.Hypoxia suppresses KV 2.1 channel expression through endogenous 15-hydro- xyeicosatetraenoic acid in rat pulmonary arterial. The Journal of Physiological Sciences. 2010; 60(5):373-381. (IF. 1.606)
  19、Shanshan Li, YajuanRan, Xiaodong Zheng, Xiaoping Pang, Zhigang Wang, Rong Zhang, Daling Zhu. 15-HETE Mediates Sub-acute Hypoxia-induced TRPC Expression and Elevated Intracellular Ca2+ in rat distal pulmonary arterial myocytes. Prostaglandins and Other Lipid Mediators. 2010;93(1-2):60-74. (IF. 2.705)
  20、ShuangZhang, Yun Liu, Shouli Guo, Jianing Zhang, Xiaojie Chu, Chun Jiang, Daling Zhu. Vasoactive intestinal polypeptide relaxes isolated rat pulmonary artery rings through two distinct mechanisms. The Journal of Physiological Sciences.2010;60(6):389-397. (IF. 1.606)
  21、Lei Zhang, JunMa, YaqianLi, LeiGuo, Yajuan Ran, Shulin Liu, Chun Jiang, Daling Zhu. 15-Hydroxyeicosatetraenoic Acid (15-HETE) Protects Pulmonary Artery Smooth Muscle Cells against Apoptosis via HSP90. Life Sciences. 2010; 87(7-8):223-231.(IF. 2.527)
  22、Jing Jiang, Shuang Wang, Zhigang Wang, Jun Ma, Shulin Liu, Weiyang Li, Daling Zhu. The role of ERK1/2 in 15-HETE-inhibited apoptosis in pulmonary arterial smooth muscle cells.  Journal of Receptors and Signal Transduction. 2011 ;31(1):45-52. (IF. 1.517)
  23、Yun Liu, Ruifang,Wang , Jin Li, Jingjing Rao, Weiyang Li, John R Falck, Vijay L Manthati, Meetha Medhora, Elizabeth R Jacobs and Daling Zhu. Stable EET urea agonist/sEH inhibitor regulates rat pulmonary arteries through TRPC channels. Hypertension Research.  2011; 34(5):630-639. (IF. 2.576)
  24、Cui Ma, Yaqian Li,  Jun Ma, Yun Liu, Qian Li, Shengpan Niu, Zhiying Shen, Lei Zhang,  Zhenwei Pan, Daling Zhu*. Key Role of 15-LO/15-HETE in Pulmonary Vascular Remodeling and Vascular Angiogenesis Associated with Hypoxic Pulmonary Hypertension. Hypertension. 2011;58(4):679-688. (IF. 6.873)
  25、Xiaowei Nie, Shasha Song, Lei Zhang, Zhaoping Qiu, Shuai Shia, Yun Liu, Lan Yao, Daling Zhu*. 15-Hydroxyeicosatetraenoic Acid (15-HETE) protects pulmonary artery smooth muscle cells from apoptosis via inducible Nitric Oxide Synthase (iNOS) pathway. Prostaglandins and Other Lipid Mediators.  2012 97(1-2):50-9. (IF. 2.705)
  26、Jun Ma, Lei Zhang, Weina Han, Tingting Shen, Cui Ma, Mengmeng Liu, Yun Liu, Yanyan Wang, Yajuan Ran, Daling Zhu*. Activation of JNK/c-Jun pathway is required for the cell proliferation, survival and angiogenesis by epoxyeicosatrienoic acids in pulmonary arterial endothelial cells.  Journal of Lipid Research 2012;53(6):1093-10 (IF. 4.386)
  27、Lei Guo, Zhaoping Qiu , Liuping Wei, Xiufeng Yu, Xu Gao, Shulin Jiang, Hai Tian, Chun Jiang, Daling Zhu*. The miR-328 regulates hypoxic pulmonary hypertension by targeting at IGF-1R and CaV1.2. Hypertension 2012;59:1006-1013  (IF. 6.873)
  28、Yun Liu, Jing Zhang, Lei Yu, Fangyuan Cao, Jingjing Rao, Jing Li, Chun Jiang, J.R. Falck, Elizabeth R Jacobs, Daling Zhu*. A soluble epoxide hydrolase inhibitor-8-HUDE increases pulmonary vasoconstriction through inhibition of KATP channels. Pulmonary Pharmacology and Therapeutics. 2012 Feb; 25(1):69-76  (IF 2.8)
  29、Lei Yu, Yun Liu, Zhaoping Qiu, Yali Wang, Shulin Liu, Weiyang Li, Chun Jiang, and Daling Zhu*. Cellular Mechanisms and Intracellular Signaling Pathways for the Modulation of eNOS in Pulmonary Arteries by 15-HETE.  Journal of Receptors and Signal Transduction. 2012; 32(2):87-95 (IF. 1.517)
  30、Yun Liu, Cui Ma, Qianlong Zhang, Lei Yu, Jun Ma, Lei Zhang, Xuewei Hao, Fangyuan Cao, Lin Wang, Daling Zhu. Novel Interactions between TGF-β1/Alk5 and the 15-Lipoxygenase Signaling Pathway in Pulmonary Artery Smooth Cells. The International Journal of Biochemistry & Cell Biology 2012 ;44(7):1184-202  (IF. 4.156)
  31、Jingjing Rao, Jing Li, Yun Liu and Daling Zhu*. The role of PGC-1α regulated mitochondrial biogenesis in hypoxic pulmonary hypertension. Molecular and Cellular Biochemistry. 2012 ;367(1-2):9-18 (IF. 2.329)
  32、Lei Zhang, Jun Ma, Tingting Shen, Shuang Wang, Cui Ma, Yun Liu, Mengmeng Liu, Yajuan Ran, Yanyan Wang, Lin Wang, Lijuan Liu, Daling Zhu*. Platelet-derived growth factor (PDGF) induced pulmonary vascular remodeling through 15-LO/15-HETE pathway under hypoxic condition. Cellular Signalling  2012 ;24(10):1931-9 (IF. 4.304)
33、Dandan Zhang, Cui Ma, Shanshan Li, Yajun Ran, Jianguo Chen, Jingjing Rao, Ping Lu, Shuai Shi, Daling Zhu*.  Effect of Mitofusin 2 on the proliferation of Pulmonary Smooth Muscle Cells in Hypoxic Pulmonary Hypertension. Microvasc Res. 2012 ; 84(3):286-96. (IF.2.828)  
  34、Lan Yao, Xiaowei Nie, Shuai Shi, Shasha Song, Xuewei Hao, Shuzhen Li, Daling Zhu*. Positive feedback regulation between HIF-1α and 15-LO/15-HETE promotes anti-apoptosis in hypoxia pulmonary artery smooth muscle cells. Prostaglandins and Other Lipid Mediators. 2012 ; 99(3-4):96-106. (IF. 2.705)
  35、Li Yao, Ping Lu, Yumei Li, Lijing Yang, Hongxuan Feng, Yong Huang, Daling Zhu*. Osthole, a potential Pulmonary vasodilator, relaxes small pulmonary arteries through endothelial Phosphatidylinositol 3-Kinase /Akt /eNOS /NO signaling pathway in rats. European Journal of Pharmacology 2012 7;699(1-3):23-32. (IF. 2.516)
  36、Qian Li, Shengpan Niu, Reifang Wang, Yumei Li, Rong Zhang and Daling Zhu*. Mechanisms That Underlie the Induction of Vasodilation in Pulmonary Artery by Rutin. International Angiology. 2012 Dec;31(6):557-64 (IF. 1.208)
  37、Xiaowei Nie, Yang Hui, Shuai Shi, Zhaoping Qiu, Zhenwei Pan, Qian Li, Shengpan Niu, Shuang Wang, Xu Gao and Daling Zhu*. Heme Oxygenase-1 induces 15-lipoxygenase (15-LO) expression during hypoxia-induced pulmonary hypertension. The International Journal of Biochemistry & Cell Biology 2013;45(5):964-72 (IF.4.152)
  38、Jing Li, Jingjing, Luping Wei, Yun Liu, Yonggang Cao, Xiaojiao Sun, Yueming Zhang, Qianlong Zhang, and Daling Zhu*. 15-hydroxyeicosatetraenoic Acid Promotes Chronic Hypoxia-induced Pulmonary Artery Inflammation via Positive Interaction with NF-kappaB.  Arteriosclerosis Thrombosis and Vascular Biology  2013;33(5):971-9 (IF.6.32)  
  39、Jun Ma, Lei Zhang, Jianguo Zhang,Mengmeng Liu, Liuping Wei, Yingli Chen, Lijuan Liu, Daling Zhu* 15-Lipoxygenase-1/15-hydroxyeicosatetraenoic acid promotes hepatocellular cancer cells growth through Akt/Hsp90 complex activation. The International Journal of Biochemistry & Cell Biology  2013 ;45(6):1031-41 (IF.4.152)
  41、Shasha Song; Shuang Wang; Jun Ma; Lan Yao; Hao Xing; Lei Zhang; Lin Liao; Daling Zhu*.Biliverdin reductase/bilirubin mediates the anti-apoptotic effect of hypoxia in pulmonary arterial smooth muscle cells through ERK1/2 pathway. Experimental Cell Research  2013 1;319(13):1973-87(IF.3.58)
  42、Cui Ma, Yanyan Wang, Tingting Shen,Cui Ma,Chen Zhang, Daling Zhu*. PLGF mediates Angiogenesis in hypoxic induced Pulmonary hypertension. Prostaglandins, Leukotrienes & Essential Fatty Acids. 2013 Sep;89(4):159-68 (IF.2.7)
  43、Tingting Shen, Jun Ma, Lei Zhang, Xiufeng Yu, Mengmeng Liu, Yunlong Hou, Yanyan Wang, Cui Ma, Shuzhen Li, Daling Zhu*. Reciprocal Regulation of 15-LO and 15-HETE by TERT: A Positive-feedback Loop Propelling Pulmonary Hypertension  PloS One 2013 Dec 23;8(12):e83132 (IF3.73)
  44、Shanshan Li, Yajuan Ran, Dandan Zhang, Shuzhen Li, and Daling Zhu *. MicroRNA-190 regulates hypoxic pulmonary vasoconstriction by targeting a voltage-gated K+ channel in arterial smooth muscle cells. Journal of Cellular Biochemistry 2014 Jan 20. doi: 10.1002/jcb.24771. [Epub ahead of print] (IF. 3.06)
  45、Cui Ma,Yun Liu, Yanyan Wang, Chen Zhang, Hongmin Yao,Jun Ma,Lei Zhang,Dandan Zhang,Tingting Shen, Daling Zhu*. Hypoxia activates 15-PGDH and its metabolite 15-KETE to promote pulmonary artery endothelial cells proliferation via ERK1/2 signaling. British Journal of Pharmacology 2014 Jan 28. doi: 10.1111/bph.12594. [Epub ahead of print] (IF. 5.04)
  46、Li Zhang, Yumei Li, Minggang Chen, Dan Yi, Ping Lu, Lijuan Liu , Xiufeng Yu, Yan Xin, Guixia Li, and Daling Zhu*. 15-LO/15-HETE medicates rat vascular adventitia fibrosis via TGF-β1 /Smad pathways  Journal of Cellular Physiology. 2014 Feb;229(2):245-57 (IF. 4.218)
  47、Praveen kumar Sugumaran, Shuang Wang, Shuai Shi, Ping Lu, Xiaowei Nie, Shasha Song, Daling Zhu. 15-KETE activates pro-survival pathway to inhibit serum deprived apoptosis in pulmonary arterial smooth muscle cells. Prostaglandins, Leukotrienes & Essential Fatty Acids. 2014 Feb 10. pii: S0952-3278(14)00020-9. doi: 10.1016/j.plefa.2014.01.006. [Epub ahead of print] (IF.2.7)
  48、Xiaowei Nie, Yun Liu, Dongsu Chen, Lei Zhang, Shuang Wang and Daling Zhu*. HIF-1α regulates iNOS expression in the anti-apoptotic process in pulmonary artery smooth muscle cells during HPH Canadian Journal of Physiology and Pharmacology (IF1.954)  Accepted
  科研奖励: (第一完成人)
  1、朱大岭等:肺动脉高压发病的分子机制及治疗药物的研究,黑龙江省政府一等奖(自然科学类),2013,
  2、朱大岭等:15-脂氧酶/15-羟基二十四碳四稀酸在缺氧性肺动脉高压发病中的作用,教育部,高等学校科学研究优秀成果,二等奖,2010
  3、朱大岭等:,ERK1/2途径活化与15-HETE收缩缺氧大鼠肺动脉的关系,黑龙江省政府自然科学,三等奖,2009
  4、朱大岭等:,细胞色素P450系统在内外源物质代谢中的作用,黑龙江省省政府,年自然科学,二等奖,2008
  5、朱大岭等:,15-HETE致缺氧性肺动脉高压的分子和离子通道机理,黑龙江省省政府自然科学,二等奖,2006
  6、朱大岭,国务院,政府特殊津贴获得者,2006
  发明专利:
  1、朱大岭、唐晓波、武正华、王志刚、纪宏宇、于磊,分泌人羧酸酯酶2的杂交瘤细胞株及其单克隆抗体,200610,中国200610009931.3
  2、朱大岭、唐晓波、武正华、王志刚、纪宏宇、于磊,一种抗人CYP4A11多肽,200610,中国200610010458.8
  3、唐晓波,朱大岭,刘海英,杨微,武正华,王志刚,于磊,纪宏宇,戴丽娟,一种CYP1A2多肽,200610,中国200610010342.7
 
 
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